Original ArticlesRegeneration of Cystic Bone Cavities and Bone Defects With Bioactive Glass S53P4 in the Upper and Lower JawsStoor, Patricia MD, PhD*; Apajalahti, Satu DDS, PhD†; Kontio, Risto MD, PhD†Author Information *Department of Oral and Maxillofacial Surgery, Helsinki University Hospital †Department of Radiology, University of Helsinki and HUS Radiology (Medical Imaging Center), Helsinki, Finland. Address correspondence and reprint requests to Patricia Stoor, MD, PhD, Department of Oral and Maxillofacial Surgery, Helsinki University Hospital, Haartmaninkatu 4 E, 000 29 HUS, Helsinki, Finland; E-mail: email@example.com Received 6 October, 2016 Accepted 4 January, 2017 The study was approved by the Ethical Committee of the Helsinki University Hospital Area with permission of research. The authors report no conflicts of interest. Journal of Craniofacial Surgery: July 2017 - Volume 28 - Issue 5 - p 1197-1205 doi: 10.1097/SCS.0000000000003649 Buy Metrics Abstract Cysts and tumors are common lesions in the jaws. To be able to retain a good volume of the alveolar ridge during healing as well as strengthening the angle and body of the mandible and provide an instant improved support for adjacent teeth, reliable long-term bone regeneration is needed. The purpose of this prospective study was to promote bone regeneration by filling bony defects in the upper or lower jaw with granules of the bioactive glass S53P4 (BAG), which have osteostimulative and antimicrobial properties. The authors treated 20 patients (21 defects) surgically; benign tumors, cysts, or infection related to impacted teeth in the maxilla or mandible. The tumor or cyst was removed or enucleated and thorough cleaning of the infected area was performed. The bone cavity was filled with granules of the BAG S53P4 despite signs of chronic infection in the area at the time of surgery. The patients were followed up for an average of 34 months clinically and with cone beam computerized tomography for 28 months. In 20 defects the final outcome was successful. Despite infection at the time of surgery in 65% of the patients, no material associated infection was seen during the follow-up. The BAG S53P4 granules were radiologically remodeled into bone after 2 years follow-up. The use of granules of the BAG S53P4 in the treatment of large bone defects provides infection-free reliable bone regeneration despite chronic infection at the time of surgery, which improves the prognosis of adjacent teeth. © 2017 by Mutaz B. Habal, MD.