Brief Clinical StudiesUnusual Presentation of Castleman Disease in the Oral CavityAnitua, Eduardo MD, PhD*; Piñas, Laura DDS*; Alkhraisat, Mohammad H. DDS, PhD†Author Information *Eduardo Anitua Clinic †Eduardo Anitua Foundation, Vitoria, Spain. Address correspondence and reprint requests to Eduardo Anitua, MD, DDS, PhD, Eduardo Anitua Foundation, c/ Jose Maria Cagigal 19, 10007 Vitoria, Spain; E-mail: email@example.com Received 5 September, 2016 Accepted 21 October, 2016 The authors report no conflicts of interest. Journal of Craniofacial Surgery: May 2017 - Volume 28 - Issue 3 - p e218-e219 doi: 10.1097/SCS.0000000000003401 Buy Metrics Abstract Castleman disease (CD) is a benign lymphoproliferative disease of unknown aetiology that rarely occurs in the head and neck region. Herein, the authors describe a patient of intraoral CD and its management. A 55-year-old female patient attended our clinic because of a 1-year history of a mass in the posterior hard palate region. Clinical and radiographic examination (cone-beam computed tomography scan), fine-needle aspiration, and incisional biopsy were performed. Both radiographic examination and fine-needle aspiration did not reveal relevant findings. The pathological analysis of the biopsy gave the diagnosis of hyaline vascular-type CD. The patient was treated by a complete surgical resection and 3 years after the treatment, the patient remained free of recurrence. Castleman disease in hard palate is quite different from other forms of cervical CD, mimicking other conditions like pleomorphic adenoma, lymphoma, and nodular necrotizing sialometaplasia. Careful clinical examination and histopathological analysis are essential for the diagnosis of rare and unusual pathological changes in the oral mucosa. © 2017 by Mutaz B. Habal, MD.