Clinical StudiesAggressive Osteoblastoma in the Maxilla Unusual Lesion in the Craniofacial SkeletonSalmen, Fued Samir PhD*; Oliveira, Marina Reis PhD*; Navarro, Cláudia Maria PhD*; Dedivitis, Rogério Aparecido PhD†; Pereira Filho, Valfrido Antonio PhD*; Gabrielli, Mario Francisco Real PhD*Author Information *Araraquara Dental School, São Paulo State University (UNESP) †São Paulo School of Medicine, University of São Paulo (USP), Santos, Brazil. Address correspondence and reprint requests to Fued Samir Salmen, PhD, Araraquara Dental School, São Paulo State University (UNESP), Avenida Ana Costa, 221/71, Santos, São Paulo CEP 11060-001, Brazil. E-mail: firstname.lastname@example.org; email@example.com Received 25 October, 2016 Accepted 4 January, 2017 The authors report no conflicts of interest. Journal of Craniofacial Surgery: May 2017 - Volume 28 - Issue 3 - p 794-797 doi: 10.1097/SCS.0000000000003641 Buy Metrics Abstract Osteoblastomas are benign bone tumors, which are unusual in the craniofacial skeleton, being most often observed in the axial skeleton and long bones. The most common site in the maxillofacial region is the mandible and the involvement of the maxilla and paranasal sinuses is extremely rare. Although it is a benign lesion, the aggressive variant raises concerns due to its huge local destructive potential and tendency to relapse. In this clinical case, an aggressive osteoblastoma is described in a 7-year-old patient. The lesion was large and fully involved the left maxilla, including the maxillary sinus and the nasal cavity. Recurrent volume increase was observed 2 months following enucleation of the lesion and en bloc resection of the maxillary segment was performed. Histological and immunohistochemical evaluation associated with clinical and imaging findings allowed to define the tumor as an aggressive variant of osteoblastoma and not osteosarcoma, despite the aggressive behavior. The patient recovered well and no relapses were observed after 12 months following maxillary resection. © 2017 by Mutaz B. Habal, MD.