Clinical StudiesInterest of Mineralized Plasmatic Matrix in Secondary Autogenous Bone Graft for the Treatment of Alveolar CleftsNadon, Florian MD*; Chaput, Benoit MD†; Périssé, Jean MD*; de Bérail, Ambre MD*; Lauwers, Frédéric MD; Lopez, Raphaël MD Author Information *Maxillofacial and Facial Plastic Unit, University Toulouse Purpan †Plastic and Reconstructive Surgery Unit, Faculty of Medicine, University Toulouse Rangueil, Toulouse, France. Address correspondence and reprint requests to Benoit Chaput, MD, Plastic and Reconstructive Surgery Department, CHU Rangueil, 1, Avenue Jean Poulhès, 31059, Toulouse Cedex 9, France; E-mail: [email protected] Received 22 August, 2014 Accepted 2 May, 2015 The authors report no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.jcraniofacialsurgery.com). Journal of Craniofacial Surgery: October 2015 - Volume 26 - Issue 7 - p 2148-2151 doi: 10.1097/SCS.0000000000001951 Buy SDC Metrics Abstract The authors describe a new material termed mineralized plasmatic matrix (MPM), a combination of platelets, fibrin concentrate, and autogenous bone to repair alveolar cleft defects. Autogenous cancellous bone is widely used to this end because such bone affords the functionalities (osteogenesis, osteoinduction, and osteoconduction) required for successful outcomes. To optimize these features, autologous blood products high in platelet concentrations have recently been developed. On the basis of our experience with PRP (platelet-rich plasma) and PRF (platelet-rich fibrin), we developed MPM, which contains platelets and fibrin concentrate in a liquid state; these materials can become bound to bone particles. The filling material is easy to shape and a PRF-type membrane is also generated. Ten patients with cleft lips and alveoli, with or without cleft palates (median, or uni- or bilateral) benefited from secondary bone grafts placed using our new material. We transferred autogenous bone from the iliac crest, an abundant source of cancellous bone associated with a high success rate. The 6-month outcomes of all patients were excellent in terms of both bone graft stability and closure of the oronasal fistulae. The preparation procedure is simple and the technical requirements minimal. Upon further optimization, MPM may serve as a third-generation platelet concentrate with potential applications in various fields. © 2015 by Mutaz B. Habal, MD.