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Primary Diffuse Large B-Cell Dural Lymphoma With Bone and Subcutaneous Tissue Involvement Mimicking Meningioma

Wang, Long MD*; Ouayang, Taohui MD; Zhang, Na MD; Song, Zhibin MD*; Gao, Jianwei MD*; Li, Xuguang MD*; Wang, Fang MD§

doi: 10.1097/SCS.0000000000002007
Brief Clinical Studies
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Primary dural lymphoma (PDL), a rare subtype of primary central nervous system lymphoma (PCNSL), is usually a marginal zone B-cell lymphoma or low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type. Primary dural invasion by diffuse large B-cell lymphoma is extremely rare, with only a few cases reported in the literature. The authors presented an unusual case of primary dural involvement by a high-grade diffuse large B-cell lymphoma that invaded parietal bone and subcutaneous tissue. The patient received tumor complete resection and cranioplasty as well as radiotherapy and chemotherapy as adjuvant treatment after surgery. During 12 months follow-up, no tumor recurrence was found. Primary dural lymphoma should be differentially diagnosed with meningioma. Once the diagnosis of PDL is established, tumor resection and adjuvant radiation and chemotherapy may obtain relatively good prognosis.

*Department of Neurosurgery, Affiliated Heping Hospital of Chang Zhi Medical College, Chang Zhi, Shanxi

Department of Neurosurgery

Department of Neurology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan

§Department of Endocrinology and Metabolism, Affiliated Heping Hospital of Chang Zhi Medical College, Chang Zhi, Shanxi, China.

Address correspondence and reprint requests to Fang Wang, MD, PhD, Department of Endocrinology and Metabolism, Affiliated Heping Hospital of Chang Zhi Medical College, Chang Zhi, Shanxi, China; E-mail: wjy3038556@163.com

Received 9 April, 2015

Accepted 22 May, 2015

The authors report no conflict of interest.

© 2015 by Mutaz B. Habal, MD.