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Multiple Subungual Pyogenic Granulomas Following Levothyroxine Treatment

Keles, Musa Kemal MD*; Yosma, Engin MD; Aydogdu, Ilhami Oguzhan MD; Simsek, Tekin MD; Park, Tae Hwan MD‡,§

doi: 10.1097/SCS.0000000000001922
Brief Clinical Studies

Pyogenic granulomas are benign vascular lesions that can result from a large number of etiological factors. Drugs are one etiological factor involved in pyogenic granuloma development. In this study we present our experience of multiple pyogenic granulomas following levothyroxine administration suggesting that levothyroxine hormone replacement therapy might play an important role in the formation of pyogenic granuloma. We also reviewed the literatures regarding drug-induced pyogenic granulomas.

*Department of Plastic Surgery, Numune Hospital, Konya, Turkey

Department of Plastic Surgery, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey

Department of Plastic Surgery, Buleun Health Care Center, Incheon, Republic of Korea

§Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, South Korea.

Address correspondence and reprint requests to Tae Hwan Park, Buleun Health Care Center, Gangwha dongro 562–3, Incheon 417–832, Republic of Korea; E-mail:

Received 26 February, 2015

Accepted 31 March, 2015

The authors report no conflicts of interest.

© 2015 by Mutaz B. Habal, MD.