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Propolis Accelerates the Consolidation Phase in Distraction Osteogenesis

Bereket, Cihan PhD, DDS*; Özan, Fatih PhD, DDS; Şener, İsmail PhD, DDS*; Tek, Mustafa PhD, DDS; Altunkaynak, Berrin Zuhal MD; Semirgin, Sibel Uçak MD§; Şenel, Erman DDS*; Özdemir, Muhsin DDS*

The Journal of Craniofacial Surgery: September 2014 - Volume 25 - Issue 5 - p 1912–1916
doi: 10.1097/SCS.0000000000000946
Scientific Foundation

We evaluated the effect of propolis on new bone formation after distraction osteogenesis (DO). This study examined 3 groups: control group, P100, and P200. Rabbits underwent DO of the left mandible after an osteotomy between the first molar and the mental foramen. Bone mineral content and bone mineral density were evaluated using dual-energy x-ray absorption 1 and 4 weeks after the procedure. The volume of connective tissue and new bone and the number of capillaries were measured using stereologic analysis after the subjects were killed. Dual-energy x-ray absorption showed that the bone mineral content and bone mineral density were higher in the groups treated with propolis by week 4, and these parameters were higher in the P200 group. Stereologic analysis showed no significant differences in connective tissue volume and number of capillaries among the groups. New bone volume was lowest in the P200 group. We concluded that propolis accelerates bone formation and may shorten the consolidation phase with DO.

From the *Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ondokuz Mayıs University, Samsun, Turkey; †Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Abant Izzet Baysal University, Bolu, Turkey; and Faculty of Medicine, Departments of ‡Histology and Embriology and §Nuclear Medicine, Ondokuz Mayıs University, Samsun, Turkey.

Received January 3, 2014.

Accepted for publication February 17, 2014.

Address correspondence and reprint requests to Fatih Özan, Diş Hekimliği Fakültesi, Ağız Diş ve Çene Cerrahisi Anabilim Dalı, Abant İzzet Baysal Üniversitesi, Şehir Kampüsü, Bolu, 14100 Turkey; E-mail:

The authors report no conflicts of interest.

© 2014 by Mutaz B. Habal, MD.