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Effects of the Hyperbaric Oxygen on De Novo Bone Formation During Periosteal Distraction

Suer, Berkay Tolga DDS, PhD*; Ortakoglu, Kerim DDS, PhD; Gunaydin, Yilmaz DDS, PhD; Sencimen, Metin DDS, PhD§; Mutlu, Ibrahim DDS, PhD; Dogan, Necdet DDS, PhD§; Kaya, Ayper MD

The Journal of Craniofacial Surgery: September 2014 - Volume 25 - Issue 5 - p 1740–1745
doi: 10.1097/SCS.0000000000000996
Original Articles
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Objective The purpose of this study was to investigate the effect of hyperbaric oxygen (HBO) therapy on de novo bone formation during periosteal distraction (PD).

Materials and Methods Periosteal distraction was performed in 24 mature male New Zealand rabbits using a custom-designed device placed on the lateral surface of the mandibular corpus. Twelve rabbits (group H) were given adjunctive HBO treatment, whereas 12 rabbits (group N) were kept in a normal environment (normobaric oxygen). After a 7-day latency period, the same distraction protocol was applied to both groups. However, the rabbits in group H were treated with pure oxygen at 2.4 atm absolute for 25 times. Both groups were further divided into 2 subgroups and killed after consolidation periods of 4 and 8 weeks. Photodensitometric and histologic analyses were performed to evaluate the newly formed bone.

Results There was no significant difference between the 4-week consolidated HBO group and the 8-week consolidated normobaric oxygen subgroup (P = 0.229). Moreover, there was better bone formation in the 8-week HBO group than in the 8-week control group.

Conclusion The results of this study indicate that PD with HBO could be used to increase the quality and the quantity of the bone newly formed by PD.

From the *Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy (GMMA), Haydarpasa Teaching Hospital; †Service of Dental Medicine, Medicana Hospital, Istanbul; §Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy (GMMA), Etlik; ∥Department of Dental Medicine, Tatvan Military Hospital, Tatvan; ‡Private Practice, Ankara; and ¶Kasimpasa Military Hospital, Kasimpasa, Istanbul, Turkey.

Received November 13, 2013.

Accepted for publication April 7, 2014.

Address correspondence and reprint requests to Berkay Tolga Suer, DDS, PhD, Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy (GMMA), Haydarpasa Teaching Hospital, Uskudar, 34668, Istanbul, Turkey; E-mail: berkaysuer@hotmail.com

The authors report no conflicts of interest.

© 2014 by Mutaz B. Habal, MD.