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Does Oral Clonidine Premedication Decrease Bleeding During Open Rhinoplasty?

Tabrizi, Reza DMD, MD*; Eftekharian, Hamidreza MD; Pourdanesh, Freydoun DMD; Khaghaninejad, Mohammad Saleh DMD§

Journal of Craniofacial Surgery: May 2014 - Volume 25 - Issue 3 - p 1101–1103
doi: 10.1097/SCS.0000000000000660
Brief Clinical Studies

This uni–blind randomized clinical trial study investigated the effect of clonidine premedication on preoperative blood loss during open rhinoplasty. The subjects were randomly divided into 2 groups. The members of the first group received oral clonidine as a single dose (0.2 mg) 2 hours before the induction of general anesthesia, whereas the members of the second group received a placebo. All subjects underwent open rhinoplasty without septoplasty.

One anesthetic protocol was followed for all subjects. Variable factors include the subjects’ weight, age, sex, and blood pressure during the surgery as well as blood loss during rhinoplasty. Group 1 consisted of 22 women and 11 men, whereas group 2 was composed of 16 women and 17 men. The mean for blood loss amounted to 68.03 ± 22.49 mL for group 1 and 132.12 ± 78.53 mL for group 2. An assessment demonstrated a significant difference in blood loss between the 2 groups (P < 0.001.) Oral clonidine premedication thus may decrease preoperative bleeding during open rhinoplasty.

From the *Department of Maxillofacial Surgery, Shahidbeheshti University of Medical Science, Tehran; †Department of Anesthesiology, Shiraz University of Medical Science, Shiraz; ‡Department of Maxillofacial Surgery, Shahidbeheshti University of Medical Sciences, Tehran; and §Department of Maxillofacial Surgery, Shiraz University of Medical Science, Shiraz, Iran.

Received September 13, 2013.

Accepted for publication December 26, 2013.

Address correspondence and reprint requests to Reza Tabrizi, DMD, MD, Oral and Maxillofacial Surgery Department, Shahidbeheshti Dental School, Velenjak, Tehran, Iran; E-mail:

The authors report no conflicts of interest.

© 2014 by Mutaz B. Habal, MD.