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Iatrogenic Rhinopharyngeal Isolated Argyria Induced by Silver-Containing Nasal Drug

Raimondo, Luca MD*; Garzaro, Massimiliano MD*; Molinaro, Luca MD; Bartoli, Claudia MD*; Provenzano, Erica MD*; Pecorari, Giancarlo MD*

Journal of Craniofacial Surgery: March 2014 - Volume 25 - Issue 2 - p e149–e151
doi: 10.1097/SCS.0000000000000416
Brief Clinical Studies

Localized nasal argyria has been reported in 3 published articles as secondary to occupational exposure and involving the anterior part of the nose. No previous cases of such pathology involving the rhinopharynx were described. Here we report the first case of localized argyria of the roof and of the posterior wall of the rhinopharynx secondary to prolonged use of nasal drops containing colloidal silver protein. The recognition of such pathology can be useful to increase the number of conditions that must be considered in the differential diagnosis of rhinopharyngeal mucosa alterations.

From the *1st ENT Division, Surgical Sciences Department, and †Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy.

Received May 17, 2013.

Accepted for publication September 17, 2013.

Address correspondence and reprint requests to Luca Raimondo, MD, 1st ENT Division, Surgical Sciences Department, University of Turin, Via Genova, 3-10126 Turin, Italy; E-mail:

The authors report no conflicts of interest.

© 2014 by Mutaz B. Habal, MD.