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Silk Fibroin and 4-Hexylresorcinol Incorporation Membrane for Guided Bone Regeneration

Lee, Sang-Woon DDS*; Kim, Seong-Gon DDS, PhD*; Song, Ji-Young DDS; Kweon, HaeYong PhD; Jo, You-Young PhD; Lee, Kwang-Gill PhD; Kang, Seok-Woo PhD; Yang, Byoung-Eun DDS, PhD§

doi: 10.1097/SCS.0b013e3182a3050c
Original Articles

The objective of this study was to demonstrate that a silk fibroin (SF) and 4-hexylresorcinol (4-HR) incorporation membrane could be used for a guided bone regeneration technique. Fourier transform infrared measurements were obtained to determine change of physical property of SF membrane by 4-HR incorporation. Two peri-implant defects, 3.0 × 5.0 mm (width × length), were prepared on the lateral side of the implant hole in the tibia of New Zealand white rabbits (n = 8). The peri-implant defect was left unfilled in the control group. Silk fibroin + 4-HR membrane was applied to the peri-implant defect in the experimental group. The 8 animals were killed at 8 weeks after implantation. Subsequently, removal torque test and histomorphometric evaluation were done. Fourier transform infrared spectroscopy showed no specific chemical interaction between 4-HR and SF. In the histomorphometric analysis, the mean bone regeneration was 18.3 ± 1.9 mm2 in the experimental group and 9.3 ± 0.9 mm2 in the control group (P = 0.004). In conclusion, the SF and 4-HR incorporation membrane successfully regenerated bone in the rabbit tibia peri-implant bone defect model.

From the *Department of Oral and Maxillofacial Surgery, Gangneung-Wonju National University, Gangneung; †Department of Dentistry, Jeju National University, Jeju; ‡Sericultural and Apicultural Materials Division, National Academy of Agricultural Science, RDA, Suwon; and §Department of Oral and Maxillofacial Surgery, Sacred Heart Hospital, Hallym University, Anyang, Republic of Korea.

Received February 12, 2013.

Accepted for publication June 30, 2013.

Address correspondence and reprint requests to Seong-Gon Kim, DDS, PhD, Gangneung-Wonju National University-College of Dentistry, Gangneung, 210-702, Republic of Korea; E-mail:

This work was supported by a grant from the Next-Generation BioGreen 21 Program (no. PJ009013) Rural Development Administration, Republic of Korea.

The authors report no conflicts of interest.

© 2013 by Mutaz B. Habal, MD.