The aim of this study was to examine the changes of the synovial tissue in rabbit temporomandibular joint (TMJ) internal derangement (ID) models using light and electron microscope. Thirteen rabbits were included in our study. The right TMJ of all animals were used as the experimental group while the left ones as the control group. ID model was established by using elastic rubber rope to stretch anteriorly. Synovial tissues were collected and examined by light and electron microscope to observe microstructure and ultrastructure changes after establishing the model. CD34 was used to count small blood vessels. A paired t test was performed with SPSS 16.0 software package to compare the data of the experimental and the control side. The average number of small blood vessels in the experimental side was significantly greater than the control side both in the first and second week. Numerous synovial cells of type A and type B were detected under electron microscope, and type A cells shrunk after a period of time. This study is helpful to understand the development of the TMJ intra-articular adhesion.
From the *Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology; †Shanghai Jiao Tong University School of International and Public Affairs, Shanghai, People’s Republic of China; and ‡Department of Oral and Maxillofacial Surgery, Madigan Army Medical Center, Tacoma, WA.
Received August 22, 2012.
Accepted for publication December 8, 2012.
Address correspondence and reprint requests to ShanYong Zhang, MD, Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, No. 639 Zhi Zao Ju Road, 200011 Shanghai, People’s Republic of China; E-mail: firstname.lastname@example.org
ShanYong Zhang and Pei Shen contributed equally to this work.
This study was supported by the grant of Shanghai Leading Academic Discipline Project (Project Number S30206), grant from Shanghai Municipal Bureau of Health (Grant No. 2008160), and grant from the National Natural Science Foundation of Shanghai (No. 10ZR1418200).
The authors report no conflicts of interest.