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Radiographic Evaluation of Regenerated Bone Following Poly(Lactic-Co-Glycolic) Acid/Hydroxyapatite and Deproteinized Bovine Bone Graft in Sinus Lifting

y Baena, Ruggero Rodriguez MD, DDS*; Lupi, Saturnino Marco DDS*; Pastorino, Roberta MEng, PhD; Maiorana, Carlo MD, DDS; Lucchese, Alessandra DDS, MSOrth§; Rizzo, Silvana MD, DDS*

Journal of Craniofacial Surgery: May 2013 - Volume 24 - Issue 3 - p 845–848
doi: 10.1097/SCS.0b013e31827ca01a
Original Articles

Although numerous biomaterials are used for maxillary sinus-lift surgery, the ideal material for such procedures has not yet been identified. Both heterologous and alloplastic bone substitutes have a solely osteoconductive effect and lack the osteoinductive properties of the bone morphogenetic proteins typical of autologous bone. Our group assessed a new alloplastic graft material, poly(lactic-co-glycolic) acid/hydroxyapatite (PLGA/HA), implanted in a human model of maxillary sinus-lift surgery. For this prospective, random, double-blind trial, we used deproteinized bovine bone (DBB) as the comparison material. Radiographic bone vertical height and density were assessed at approximately 28 weeks after grafting using cone-beam computed tomography. The vertical dimension of the regenerated bone was equivalent between the 2 groups. The density of the bone regenerated using PLGA/HA was significantly lower than that obtained with DBB. Despite clinical assessments demonstrating that PLGA/HA has sufficient characteristics for use in sinus-lift surgery, DBB provided greater bone density and an equivalent vertical dimension of grafted bone. Further studies are needed to supplement the radiologic findings with histologic and micromorphometric examinations.

From the *Department of Clinico Surgical, Diagnostic and Pediatric Sciences, School of Dentistry, and †Department of Public Health, Neurosciences, Experimental Forensic Medicine, University of Pavia, Pavia; ‡Foundation IRCCS Policlinico Ca’ Granda, University of Milan, Milan; and §Department of Medical-Surgical Sciences of Communication and Behaviour, School of Dentistry, University of Ferrara, Ferrara, Italy.

Received October 28, 2012.

Accepted for publication November 4, 2012.

Address correspondence and reprint requests to Ruggero Rodriguez y Baena, MD, DDS, Department of Clinico Surgical, Diagnostic and Pediatric Sciences, University of Pavia, P.le Golgi #2, 27100, Pavia, Italy; E-mail:

This research was supported by Intra-lock System Europa, Salerno, Italy.

The authors report no conflicts of interest.

© 2013Wolters Kluwer Health | Lippincott Williams & Wilkins