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Oral Lesions in Renal Transplant

da Silva, Luiz Carlos Ferreira DDS, PhD, MSc*; de Almeida Freitas, Roseana DDS, PhD, MSc; de Andrade, Manoel Pacheco Jr MD*; Piva, Marta Rabello DDS, PhD, MSc*; Martins-Filho, Paulo Ricardo Saquete DDS, MSc*; de Santana Santos, Thiago DDS, Msc

Journal of Craniofacial Surgery: May 2012 - Volume 23 - Issue 3 - p e214–e218
doi: 10.1097/SCS.0b013e31824de388
Brief Clinical Studies

To prevent rejection of kidney transplants, patients must be kept in immunosuppressive therapy for a long time, which includes the use of drugs such as cyclosporine, azathioprine, cyclophosphamide, and prednisone. The action of these drugs reduces the general immune response of transplant patients and thus increases their susceptibility to infections. Moreover, these drugs increase the potential of developing lesions. Therefore, oral hygiene in kidney transplant recipients contributes to maintenance of the transplanted organ and its function. Thus, an investigation of oral lesions could be counted as a notable work. The aim of this study was to investigate oral lesions in a group of 21 kidney transplant patients under immunosuppressive therapy attended during a 1-year period in the Nephrology Department of the Federal University of Sergipe, Brazil. Data related to sex, age, etiology of renal disease, types of renal transplant, time elapsed after transplantation, immunosuppressive treatment, use of concomitant agents, and presence of oral lesions were obtained. All patients received a kidney transplant from a living donor, and the mean posttransplantation follow-up time was 31.6 months; 71.5% used triple immunosuppressive therapy with cyclosporine A, azathioprine, and prednisone. Ten patients were also treated with calcium-channel blockers. Of the 21 transplant patients, 17 (81%) presented oral lesions. Gingival overgrowth was the most common alteration, followed by candidiasis and superficial ulcers. One case of spindle cell carcinoma of the lower lip was observed. Oral cavity can harbor a variety of manifestations related to renal transplantation under immunosuppressive therapy.

From the *Federal University of Sergipe, Aracaju; †Federal University of Rio Grande do Norte, Natal; and ‡University of São Paulo, Ribeirão Preto, Brazil.

Received August 18, 2011.

Accepted for publication November 20, 2011.

Address correspondence and reprint requests to Luiz Carlos Ferreira da Silva, DDS, PhD, MSc, Hospital Universitário, Departamento de Odontologia, Universidade Federal de Sergipe, Rua Cláudio Batista, s/n Bairro Sanatório, Aracaju, SE, Brazil CEP 49060-100; E-mail:

The authors report no conflicts of interest.

© 2012 Mutaz B. Habal, MD