The aim of this study was to develop an internal distractor to release a drug to the distraction site during the distraction process and to investigate whether intermittent bone morphogenetic protein 2 (BMP
hydrogel infusion will improve radiologic and histologic parameters of distraction osteogenesis
(DO) when compared with control groups.
Materials and Methods:
Experimental groups were control group (n = 6), 2-μg single-dose BMP
hydrogel-infused group (n = 6), and 2-μg intermittent BMP
hydrogel-infused group (n = 6). In intermittent BMP
-infused group, certain amount of BMP
-2 loaded chitosan
hydrogel injected into the distraction gap for controlled BMP
release from the chitosan
with every turning of the geared rod of the distractor. Radiologic and histologic evaluation methods have been conducted.
The results of the analysis demonstrated that the newly developed distractor effectively stabilized the DO site while allowing intermittent BMP
infusion. Application of a BMP
hydrogel infusion to the distraction zone facilitates ossification. Intermittent infusion of BMP
hydrogel by use of a developed internal distractor increases ossification even more at the site of DO.