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Surgical Correction of Craniosynostosis in Malignant Osteopetrosis

Krimmel, Michael MD, DMD*; Niemann, Gerhard PhD, MD; Will, Bernd PhD, MD; Reinert, Siegmar PhD, MD, DMD*

Journal of Craniofacial Surgery: March 2004 - Volume 15 - Issue 2 - p 218-220
Clinical Notes

In osteopetrosis, bone healing is complicated by progressive sclerosis. A 2-year-old blind boy with malignant osteopetrosis developed increased intracranial pressure secondary to craniosynostosis. Osteopetrosis had already been treated with bone marrow transplantation (BMT), and bone remodeling seemed to be restored. A craniotomy was performed. The postoperative course and bone healing were uneventful. After successful BMT, craniofacial procedures seem to be possible without a high risk for osteomyelitis.

Tübingen, Germany

From the Departments of *Oral and Maxillofacial Plastic Surgery, Pediatrics, Developmental Neurology, and Neurosurgery, University Hospital Tübingen, Germany.

Address correspondence and reprint requests to Dr Krimmel, Klinik und Poliklinik für Mund-, Kiefer-und Gesichtschirurgie, Universität Tübingen, Osianderstrasse 2-8, D-72076 Tübingen, Germany. E-mail:

© 2004 Mutaz B. Habal, MD