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CD44 as Prognostic Factor in Oral and Oropharyngeal Squamous Cell Carcinoma

Carinci, Francesco MD*; Stabellini, Giordano PhD; Calvitti, Mario PhD; Pelucchi, Stefano MD§; Targa, Lorenza MD§; Farina, Antonio MD; Pezzetti, Furio PhD¶¶; Pastore, Antonio MD§

Journal of Craniofacial Surgery: January 2002 - Volume 13 - Issue 1 - p 85-89
Clinical Notes
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This retrospective case control study was conducted to assess the prognostic value of some patient-, tumor-, treatment-related variables, and to correlate markers of primary tumor with survival and cervical metastases. Twenty-five patients with histologically proven squamous cell carcinoma of the oral cavity and oropharynx were analyzed. Patients were never treated before and had a minimum follow-up review of 45 months.

Results show that T-stage is the most important clinical prognostic parameter. Regarding immunohistochemical markers (Ki67 and CD44), only CD44 seems to be significantly correlated with prognosis but this value showed a multicollinear effect with N upon survival. Decreased expression of CD44 correlates with a decreased survival, although increased CD44 expression was consistent with a longer survival. Therefore, it was assessed that a loss of cell adhesion, related to decreased expression of CD44, may be determinant of survival in these patients.

Ferrara, Italy

Perugia, Italy

Bologna, Italy

From the Chair of *Maxillofacial Surgery, University of Ferrara, Anatomy, University of Milano; Histology, University of Perugia; §E.N.T., University of Ferrara; Histology and Human Embryology, University of Bologna; ¶¶Histology, University of Ferrara.

Address correspondence to Dr Francesco Carinci, E.N.T. Clinic, University of Ferrara, Arcispedale S. Anna, Corso Giovecca, 203, 44100 Ferrara, Italy; E-mail: crc@unife.it

© 2002 Mutaz B. Habal, MD