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Aaboe M. DDS; Pinholt, E. M. DDS, MS, Drodont; Hjørting-Hansen, E. DOS, Drodont
Journal of Craniofacial Surgery: July 1994
Correspondence: PDF Only
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The critical-size defect is important as an experimental model to test bone repair materials. Guided tissue regeneration is an established method for tissue regeneration within periodontal surgery. Bony defects covered by a membrane are allowed to be filled by bony tissue. Healing of 8-mm unicortical trephine defects was tested in Copenhagen White rabbit tibia using 3 different membranes. The critical-size defect in Copenhagen White rabbit tibia is larger than 8 mm, because control defects 8 mm in diameter healed spontaneously. However, it is anatomically not possible to create defects larger than 8 mm in an adult Copenhagen White rabbit tibia.

© 1994 Mutaz B. Habal, MD