Case ReviewAutoimmune Small Fiber Neuropathy Associated With Ehlers–Danlos Syndrome Treated With Intravenous ImmunoglobulinsCook, Melissa K. MD; Jordan, Morgan DO Author Information Department of Neurology, Brooke Army Medical Center, Fort Sam Houston, TX. Reprints: Melissa K. Cook, MD, Neurology Clinic, Brooke Army Medical Center, 3551 Roger Brooke Dr., Fort Sam Houston, TX 78234 (e-mail: [email protected]). The authors report no conflicts of interest. The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of Brooke Army Medical Center, the U.S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of the Army, the Department of the Air Force, or the Department of Defense or the U.S. Government. Journal of Clinical Neuromuscular Disease 22(3):p 160-163, March 2021. | DOI: 10.1097/CND.0000000000000341 Buy Metrics Abstract Patients with Ehlers–Danlos syndrome (EDS) have many associated symptoms of unclear cause, most recently suggested to be due to small fiber neuropathy (SFN). Small fiber neuropathies are sorely underestimated and with minimal treatment options. We report 2 cases of patients with EDS with presumed immune-mediated SFN, successfully treated with IV immunoglobulins. There is a stark need for further investigational studies into immunosuppressant treatments for immune-mediated SFN as well as the link between EDS and immune-mediated SFN. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.