Case ReviewAcute Axonal Motor Neuropathy With Completely Reversible Conduction Failure—Is It Really Axonal?Carneiro, Fábio MD*; Sequeira, João MD†; Goulart, Zulmira MD†; Pereira, Pedro MD*Author Information *Neurology Deparment, Hospital Garcia de Orta, Almada, Portugal; and †Neurology Deparment, Centro Hospitalar Barreiro-Montijo, Montijo, Portugal. Reprints: Fábio Carneiro, MD, Hospital Garcia de Orta, Avenida Torrado da Silva, 2805-267 Almada, Portugal (e-mail: [email protected]). The authors report no conflicts of interest. Journal of Clinical Neuromuscular Disease: March 2021 - Volume 22 - Issue 3 - p 155-159 doi: 10.1097/CND.0000000000000305 Buy Metrics Abstract We present the case of a 24-year-old man with a 3-day history of limb weakness and flaccid tetraparesis, hyporreflexia, and gait difficulties (Hughes grade 3) in the examination. Electromyography at presentation revealed severe amplitude reduction in distal compound muscle action potentials of several nerves without features of demyelination, fulfilling electrodiagnostic criteria for acute axonal motor neuropathy. The patient was treated with immunoglobulin and recovered completely 21 days after symptom onset. Electromyography at this timepoint showed normalization of compound muscle action potentials without increased temporal dispersion. The electroclinical recovery profile in this patient is consistent with reversible conduction failure in distal nerve segments in detriment of axonal degeneration. Thus, it is an “axonal motor neuropathy” where axonopathy is unlikely, giving strength to the concept of “nodopathies/paranodopathies.” Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.