Original ArticleEfficacy of Electrical Stimulation on Nerve Fiber Growth in Small Fiber NeuropathyBurakgazi, Ahmet Z. MD*,† Author Information *Neuroscience Section, Department of Medicine, Virginia Tech Carilion School of Medicine, Carilion Clinic Neurology, Roanoke, VA; and †Neuroscience Section, Department of Internal Medicine. Reprints: Ahmet Z. Burakgazi, MD, Associate Professor, Virginia Tech Carilion School of Medicine, Carilion Clinic Neurology, 3 Riverside Circle, 2nd Floor, Roanoke, VA 24016 (e-mail: [email protected]). This study was sponsored by Research Acceleration Program of Carilion Clinic (intramural grant) Roanoke, VA. The author reports no conflicts of interest. Journal of Clinical Neuromuscular Disease: June 2020 - Volume 21 - Issue 4 - p 187-194 doi: 10.1097/CND.0000000000000280 Buy Metrics Abstract Objectives: To define whether electrical nerve stimulation (ENS) therapy would promote intraepidermal nerve growth and nerve regeneration in patients with small fiber neuropathy (SFN). Methods: This was a prospective study conducted on 8 subjects with previously diagnosed SFN. Nerve conduction testing, punch biopsies, and clinical examinations with a calculation of revised total neuropathy score were conducted on subjects before beginning ENS therapy and at 30 and 60 days after the start of ENS therapy. Results: Clinical examination findings and intraepidermal nerve fiber density measurements on day 30 and day 60 did not show statistically significant changes in the treated group compared with the untreated group. Conclusions: Despite the success of previous animal studies, no meaningful nerve growth and regeneration in SFN was demonstrated with ENS therapy in this study. Studies of larger subject larger populations with longer duration of ENS treatment are warranted to confirm our findings. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.