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Satisfactory Response With Achieving Maintenance Low-Dose Prednisone in Generalized Myasthenia Gravis

Abuzinadah, Ahmad R., MD, MSc*; Jabari, Duaa, MD; Jawdat, Omar, MD; Pasnoor, Mamatha, MD; Glenn, Melanie, MD; Herbelin, Laura, DS; McVey, April L., MD; Barohn, Richard J., MD; Dimachkie, Mazen M., MD, FAAN

Journal of Clinical Neuromuscular Disease: December 2018 - Volume 20 - Issue 2 - p 49–59
doi: 10.1097/CND.0000000000000219
Original Article
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Objectives: To estimate the satisfactory response rate (SR%) with achieving maintenance, low-dose prednisone in acetylcholine receptor antibody–positive generalized myasthenia gravis.

Methods: In this retrospective study, we estimate the SR% as defined by (remission/minimal manifestations status for at least 6 months using 7.5 mg or less of prednisone daily, for maintenance treatment at 2, 4, and 6 years after symptoms onset) for patients who were not taking steroid-sparing immunosuppressant (SSI) as a primary outcome and for patients taking an SSI as a secondary outcome.

Results: Forty-five patients were not taking an SSI at 2 years, 34 patients at 4 years, and 17 patients at 6 years; SR% was 44.4%, 64.7%, and 58.8%, respectively. Thirty-six patients were taking an SSI at 2 years, 22 patients at 4 years, and 15 patients at 6 years; the SR% was 50.0%, 45.4%, and 66.7%, respectively.

Conclusions: Nearly half of the generalized myasthenia gravis patients who were not taking an SSI achieved an SR.

*Neurology Division, Internal Medicine Department, King Abdulaziz University, Jeddah, Saudi Arabia; and

Neurology Department, The University of Kansas Medical Center, Kansas City, KS.

Reprints: Mazen M. Dimachkie, MD, FAAN, Neuromuscular Section, Neurology Department, The University of Kansas Medical Center, 2100 West 36th Avenue, Mail Stop 2012, Kansas City, KS 66160 (e-mail: mdimachkie@kumc.edu).

The authors report no conflicts of interest.

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