Case ReviewCase of Early Amyotrophic Lateral Sclerosis With Prominent Magnetic Resonance Imaging Plexus AbnormalitiesZubair, Adeel S. MD*; Mustafa, Rafid MD†; Amrami, Kimberly K. MD‡; Crum, Brian A. MD§Author Information *Mayo Clinic School of Medicine, Rochester, MN; †Mayo Clinic School of Graduate Medical Education, Rochester, MN; ‡Division of Musculoskeletal Radiology, Departments of Radiology and Neurologic Surgery, Mayo Clinic College of Medicine & Science, Rochester, MN; and §Department of Neurology, Mayo Clinic College of Medicine & Science, Rochester, MN. Reprints: Brian A. Crum, MD, Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 (e-mail: [email protected]). The authors report no conflicts of interest. Consent: The patient has consented to research studies at Mayo Clinic. Journal of Clinical Neuromuscular Disease: September 2018 - Volume 20 - Issue 1 - p 41-44 doi: 10.1097/CND.0000000000000206 Buy Metrics Abstract Amyotrophic lateral sclerosis is a neurodegenerative disorder, which is characterized by progressive upper and lower motor neuron signs and symptoms, resulting in progressive muscle weakness. There are very rare reports of magnetic resonance imaging (MRI) abnormalities within the nerve roots or plexus reported in amyotrophic lateral sclerosis. Here, we report a patient who presented with progressive left arm weakness and was found to have bilateral MRI plexus abnormalities. This report illustrates that MRI plexus abnormalities can be seen in amyotrophic lateral sclerosis, possibly before symptoms, and may have clinical value in the diagnostic process. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.