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What is in the Myopathy Literature?

Lacomis, David, MD

Journal of Clinical Neuromuscular Disease: March 2018 - Volume 19 - Issue 3 - p 131–134
doi: 10.1097/CND.0000000000000194
Review Article

This review is focused on recent reports of sporadic inclusion body myositis (sIBM), myopathy in patients with human immunodeficiency virus type 1 (HIV) infection, and necrotizing autoimmune myopathy with antibodies to signal recognition particle. The sIBM articles cover associations with certain genetic polymorphisms, the possible pathogenic role of anti-cytosolic 5′-nucleotidase 1A antibody, and disease-related burden and health care costs. Another article addressed the possible pathogenic role of signal recognition particle antibody in necrotizing myopathy. A series of HIV patients with overlapping features of sIBM and polymyositis are highlighted as is a report of a patient with HIV and late-onset rod-body myopathy that may have improved with immunotherapy.

Departments of Neurology and Pathology (Neuropathology), University of Pittsburgh School of Medicine, Pittsburgh, PA.

Reprints: David Lacomis, MD, UPMC-Presbyterian, Room F872, 200 Lothrop St, Pittsburgh, PA 15213 (e-mail:

The author reports no conflicts of interest.

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