Case ReviewDistal Acquired Demyelinating Symmetric Neuropathy After VaccinationGable, Karissa L. MD; Afshari, Zahra MD; Sufit, Robert L. MD; Allen, Jeffrey A. MDAuthor Information Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL. Reprints: Jeffrey A. Allen, MD, Department of Neurology, Feinberg School of Medicine, Northwestern University, 710 North Lake Shore Dr, Abbott Hall, Suite 1423, 11th Floor, Chicago, IL 60611 (e-mail: [email protected]). Drs. Gable, Afshari, and Sufit report no disclosures. Dr. Allen has performed consultancy work for Axelacare. Journal of Clinical Neuromuscular Disease: March 2013 - Volume 14 - Issue 3 - p 117-122 doi: 10.1097/CND.0b013e318285256b Buy Metrics Abstract Neuropathy after vaccination is a rare event. Chronic immune-mediated polyneuropathy developing in the postvaccination period is distinctly unusual and not well described. Almost all such patients have been reported as having typical chronic inflammatory demyelinating polyneuropathy. Distal acquired demyelinating symmetric neuropathy, unlike classic chronic inflammatory demyelinating polyneuropathy, is characterized by distally predominant sensory symptoms with no or mild distal weakness. We describe the clinical, laboratory, and neurophysiological findings of 2 patients who developed distal acquired demyelinating symmetric neuropathy after vaccination. Immunomodulatory therapy led to clinical improvement in both cases. The literature is reviewed with attention to the clinical features of chronic immune-mediated neuropathies that follow vaccination. © 2013 Lippincott Williams & Wilkins, Inc.