Case ReviewAmyotrophic Lateral Sclerosis With Positive Anti-Acetylcholine Receptor Antibodies. Case Report and Review of the LiteratureMehanna, Raja MD; Patton, Eddie L. Jr MD, MS; Phan, Cecile L. MD, BS; Harati, Yadollah MDAuthor Information Department of Neurology, Baylor College of Medicine, Houston, TX. Reprints: Raja Mehanna, MD, 6501 Fannin, NB302, Houston, TX 77030 (e-mail: [email protected]). The authors report no conflicts of interest. Journal of Clinical Neuromuscular Disease: December 2012 - Volume 14 - Issue 2 - p 82-85 doi: 10.1097/CND.0b013e31824db163 Buy Metrics Abstract Myasthenia gravis is a nerve–muscle junction disease, for which the most specific test is an increase in the anti-acetylcholine receptor antibodies (anti-AChR-Abs) titer. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting both upper and lower motor neurons. Positive AChR-Ab in patients with pure ALS are exceedingly rare. We report the case of a patient with confirmed ALS and very high levels of AChR-Ab and review the literature on this topic. © 2012 Lippincott Williams & Wilkins, Inc.