Short ReportParaneoplastic Motor Neuron Disease Associated With Purkinje Cell Autoantibody Type 1Distad, B Jane MD; Weiss, Michael D MDAuthor Information From the Department of Neurology, University of Washington School Of Medicine, Seattle, WA. Reprints: B. Jane Distad, MD, 1959 NE Pacific Street Box 356465, Seattle, WA 98195 (e-mail: [email protected]). Journal of Clinical Neuromuscular Disease: September 2010 - Volume 12 - Issue 1 - p 36-41 doi: 10.1097/CND.0b013e3181c50528 Buy Metrics Abstract Motor neuron disease has been reported as a rare result of systemic cancers, likely related to an autoimmune effecter mechanism. These patients have been described as having a more rapid onset of symptoms than typical motor neuron disease. Few of these reports demonstrate an association of a cancer-related autoantibody and with motor neuron disease. We present a 54-year-old woman with infiltrating ductal carcinoma of the breast who later developed lower motor neuron disease and was found to have Purkinje cell autoantibodies type 1. The association of lower motor neuron disease as a consequence of breast cancer with this autoantibody profile has not been described previously. This report emphasizes the importance of considering a paraneoplastic syndrome in a patient with an uncommon presentation of motor neuron disease. © 2010 Lippincott Williams & Wilkins, Inc.