Short ReportChronic Inflammatory Demyelinating Polyneuropathy and Respiratory Failure Due to Phrenic Nerve InvolvementTataroglu, Cengiz MD; Ozkul, Ayca MD; Sair, Ahmet MDAuthor Information From the Adnan Menderes University, Faculty of Medicine, Department of Neurology, Aydin, Turkey. Reprints: Ayca Ozkul, MD, Adnan Menderes University Medicine Faculty, Neurology Department, 09100 Aydin, Turkey (e-mail:[email protected]). Journal of Clinical Neuromuscular Disease: September 2010 - Volume 12 - Issue 1 - p 42-46 doi: 10.1097/CND.0b013e3181d80bdc Buy Metrics Abstract In this article, 2 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) are presented. These patients developed respiratory failure which could not be explained by any cardiac or pulmonary pathology. The first case had pure motor involvement and probable CIDP, and the second case had severe sensorial dysfunction and an ataxic picture in addition to motor symptoms. His clinical picture was compatible with distal acquired demyelinating sensory neuropathy without M protein. Electrophysiologic investigations of both patients disclosed impaired phrenic nerve conduction and neurogenic motor unit changes in the diaphragm. Both patients showed a moderate response to immunotherapy. Distal acquired demyelinating sensory and pure motor variant of CIDP can be a cause of respiratory dysfunction. Different clinical patterns of CIDP should be evaluated for phrenic nerve involvement. © 2010 Lippincott Williams & Wilkins, Inc.