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Transient Neonatal Myasthenia Gravis in a Baby Born to a Mother With New-Onset Anti-MuSK-Mediated Myasthenia Gravis

O'Carroll, Peter MD*; Bertorini, Tulio E MD*; Jacob, Glady MD*; Mitchell, Christopher W MD*; Graff, Justin MD

Journal of Clinical Neuromuscular Disease: December 2009 - Volume 11 - Issue 2 - p 69-71
doi: 10.1097/CND.0b013e3181a78280
Short Report

We describe a 30-year-old pregnant woman with undiagnosed weakness who delivered a severely weak neonate. Subsequent workup of the mother revealed myasthenia gravis with muscle-specific kinase antibodies. The infant responded to intravenous immunoglobulin and symptoms normalized. He was presumed to have an anti-muscle-specific kinase-mediated transient neonatal myasthenia gravis.

From the *University of Tennessee Health Science Center, Memphis, TN; and †Tupelo Neurology Clinic, Tupelo, MS.

Reprints: Peter O'Carroll, MD, Clinical Neurophysiology Fellow, 415 Link Building, 855 Monroe Avenue, Memphis, TN 38163 (e-mail:

© 2009 Lippincott Williams & Wilkins, Inc.