Short ReportPostcricoid Pharyngeal Carcinoma Mimicking Bulbar Amyotrophic Lateral SclerosisRubin, Devon I. MDAuthor Information Department of Neurology, Mayo Clinic, Jacksonville, FL Reprints: Devon I. Rubin, MD, Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224 (e-mail: [email protected]). Journal of Clinical Neuromuscular Disease: June 2006 - Volume 7 - Issue 4 - p 175-178 doi: 10.1097/01.cnd.0000211409.40187.dc Buy Metrics Abstract Bulbar weakness, including dysarthria, dysphagia, or progressive respiratory weakness, occurs as the presenting feature in approximately 25% of patients with amyotrophic lateral sclerosis (ALS). Misdiagnosis of ALS in patients with progressive bulbar symptoms is uncommon. This report describes a 73-year-old man who had a 10-month history of progressive hoarseness, dysphagia, and respiratory failure. The initial diagnosis was bulbar ALS. Computed tomography of his neck identified a postcricoid squamous cell carcinoma, which was causing bilateral vocal cord paralysis. To the author's knowledge, postcricoid carcinoma has not been previously described as mimicking ALS but should be considered in the differential diagnosis of bulbar ALS. © 2006 Lippincott Williams & Wilkins, Inc.