Short ReportsMyeloneuropathic Presentation of Spinal Epidural LipomatosisIzadyar, Shahram MD; Kwan, Justin Y. MD; Harati, Yadollah MDAuthor Information Department of Neurology, Baylor College of Medicine, Houston, TX Reprints: Yadollah Harati, MD, Department of Neurology, Baylor College of Medicine, Smith Tower, 6550 Fannin, Suite 1801, Houston, TX 77030 (e-mail: [email protected]). Journal of Clinical Neuromuscular Disease: March 2006 - Volume 7 - Issue 3 - p 133-140 doi: 10.1097/01.cnd.0000211400.12372.d3 Buy Metrics Abstract Spinal epidural lipomatosis (SEL) is accumulation of unencapsulated fat tissue within the epidural space of the spinal canal. The most common cause of SEL is corticosteroid therapy, whereas most of the non–corticosteroid-dependent cases are idiopathic. If unrecognized, it may result in diagnostic confusion with other neuropathic or myelopathic conditions. We report 2 cases of SEL. The first case is of a 30-year-old man who received corticosteroid therapy for an acute and probably immune-mediated demyelinating process. Subsequently, the addition of compressive effects of SEL resulted in diagnostic confusion and initial workup at other centers for spinal cord malignancy and vascular malformation. The patient's symptoms improved after decompression surgery. The second case is of a 63-year-old woman with a history of type 1 diabetes mellitus that presented with increasing numbness in the lower extremities. She was initially diagnosed with diabetic neuropathy; however, the presence of myelopathic signs led to further investigation and diagnosis of SEL. Decompression surgery resulted in improvement of symptoms. © 2006 Lippincott Williams & Wilkins, Inc.