Review ArticlesDiagnosis and Treatment of Chronic Immune-mediated NeuropathiesLatov, Norman MD, PhD*; Gorson, Kenneth C. MD†; Brannagan, Thomas H. III MD*; Freeman, Roy L. MD‡; Apostolski, Slobodan MD§; Berger, Alan R. MD¶; Bradley, Walter G. DM, FRCP∥; Briani, Chiara MD**; Bril, Vera MD††; Busis, Neil A. MD‡‡; Cros, Didier P. MD§§; Dalakas, Marinos C. MD¶¶; Donofrio, Peter D. MD∥∥; Dyck, P. James B. MD***; England, John D. MD†††; Fisher, Morris A. MD‡‡‡; Herrmann, David N. MD§§§; Menkes, Daniel L. MD¶¶¶; Sahenk, Zarife MD∥∥∥; Sander, Howard W. MD*; Triggs, William J. MD****; Vallat, Jean Michel MD†††Author Information *Weill Medical College of Cornell University, NY †St Elizabeth Medical Center, Tufts University, Boston, MA ‡Beth Israel Deaconess Hospital, Harvard University, Boston, MA §University of Belgrade, Serbia ¶Department of Neurology, University of Florida at Jacksonville, Jacksonville, FL ∥Department of Neurology, University of Miami, Miami, FL **University of Padova, Padova, Italy ††University of Toronto, Toronto, Ontario, Canada ‡‡University of Pittsburgh, Pittsburgh, PA §§Massachusetts General Hospital, Harvard University, Boston, MA ¶¶NINDS, NIH, Bethesda, MD ∥∥Wake Forest University, Winston Salem, NC ***Mayo Clinic, Rochester, MN †††Deaconess Billings Clinic, Billings, MT ‡‡‡Department of Neurology, Hines VA Hospital, Chicago, IL §§§University of Rochester, Rochester, NY ¶¶¶University of Tennessee, Memphis, TN ∥∥∥Ohio State University, Columbus, OH ****Department of Neurology, University of Florida at Gainsville, Gainsville, FL ††††Department of Neurology, Dupuytren University Hospital, Limoges, France Reprints: Norman Latov, MD, PhD, Peripheral Neuropathy Center, Weill Medical College of Cornell University, 635 Madison Avenue, New York City, NY 10022 (e-mail: [email protected]) Supported in part by a nonrestricted educational grant from Bayer Biological Products to The Neuropathy Association. Journal of Clinical Neuromuscular Disease: March 2006 - Volume 7 - Issue 3 - p 141-157 doi: 10.1097/01.cnd.0000205575.26451.e4 Buy Metrics Abstract The chronic autoimmune neuropathies are a diverse group of disorders, whose diagnosis and classification is based on the clinical presentations and results of ancillary tests. In chronic inflammatory demyelinating polyneuropathy, controlled therapeutic trials demonstrated efficacy for intravenous γ-globulins, corticosteroids, and plasmaphereis. In multifocal motor neuropathy, intravenous γ-globulins have been shown to be effective. In the other immune-mediated neuropathies, there are no reported controlled therapeutic trials, but efficacy has been reported for some treatments in non-controlled trials on case studies. Choice of therapy in individual cases is based on reported efficacy, as well as severity, progression, coexisting illness, predisposition to developing complications, and potential drug interactions. © 2006 Lippincott Williams & Wilkins, Inc.