Short ReportParotid Gland Injections of Botulinum Toxin A Are Effective in Treating Sialorrhea in Amyotrophic Lateral SclerosisScott, Kevin R MD*; Kothari, Milind J DO*; Venkatesh, Y Swami MD†; Murphy, Tamara RN*; Simmons, Zachary MD*Author Information From the *Department of Neurology, Pennsylvania State University College of Medicine, Hershey, PA; and the †Department of Neurology, University of Nevada School of Medicine, Las Vegas, NV. Received for publication June 15, 2005; accepted September 19, 2005. Reprints: Kevin R. Scott, Department of Neurology, MCH037, Penn State College of Medicine, Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033 (e-mail: [email protected]). Journal of Clinical Neuromuscular Disease: December 2005 - Volume 7 - Issue 2 - p 62-65 doi: 10.1097/01.cnd.0000188865.88167.62 Buy Metrics Abstract Objective: The objective of this study was to determine the safety and efficacy of botulinum toxin A in ameliorating refractory sialorrhea and improving quality of life in patients with amyotrophic lateral sclerosis. Materials and Methods: Six patients with bulbar ALS received bilateral parotid gland injections of botulinum toxin A. Results: No adverse effects occurred. Tissue use decreased in 5 of 7 patients at a dose of 10 units and in 3 of 4 patients at a dose of 20 units. Self-reported quality of life did not change in most. Conclusions: Parotid gland injections of botulinum toxin appear safe and may be helpful in some patients with ALS for the treatment of sialorrhea. © 2005 Lippincott Williams & Wilkins, Inc.