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Coincident Acetylcholine Receptor Antibody and Anti-Asialo GM1 Antibody in a Young Male

Toth, Cory MD, FRCPC; White, Chris MD, FRCPC

Journal of Clinical Neuromuscular Disease: December 2003 - Volume 5 - Issue 2 - p 103-107
Short Reports

Coexistence of myasthenia gravis with an immunologically mediated neuropathy syndrome is rare. We present a young male patient with a history of generalized muscle weakness and fatigue with electrophysiological evidence of both a motor neuron syndrome and a neuromuscular junction abnormality accompanied by pathologic evidence of denervation with muscle biopsy. Laboratory evidence for both acetylcholine receptor (AchR) antibodies and anti-asialo GM1 antibodies, both of high levels, was found. The patient's fatigue and weakness showed an objective response to pyridostigmine, prednisone, and immunoglobulin therapy over a period of 9 months.

From the Department of Clinical Neurosciences University of Calgary, Calgary, Alberta, Canada.

Reprints: Cory Toth, MD, FRCPC, Department of Neurological Sciences, Room 165, Heritage Medical Research Building, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta, Canada T2N 4N1 (e-mail:

© 2003 Lippincott Williams & Wilkins, Inc.