Metabolic syndrome (MetS) is associated with higher incidences of cardiovascular events and with increased mortality from coronary heart disease. There is increasing evidence that MetS presents as a proinflammatory and prothrombotic state.
The purposes of this study were to investigate the relationships among adiponectin (a marker for adipocytokines), high-sensitivity C-reactive protein (hs-CRP, a marker for inflammation), and brachial-ankle pulse-wave velocity (ba-PWV, a marker for arterial stiffness) in MetS and to identify predictors of ba-PWV, which indicates subclinical atherosclerosis.
The present study is a cross-sectional, secondary analysis of data collected as part of a longitudinal, randomized controlled trial that tested the effectiveness of a therapeutic lifestyle modification for Korean women with MetS (N = 52). We used the definition for MetS suggested by the National Cholesterol Education Program Adult Treatment Panel III.
Adiponectin was negatively correlated with hs-CRP (r = −0.316, P = .027) and ba-PWV (r = −0.284, P = .048), and hs-CRP was positively correlated with ba-PWV (r = 0.341, P = .016). Women with high hs-CRP and low adiponectin levels also had greater ba-PWV levels (P = .041). Levels of hs-CRP were independently associated with ba-PWV after adjusting for age, body mass index, and number of MetS components, whereas no independent association was identified for adiponectin.
Levels of hs-CRP may provide important prognostic information in terms of future cardiovascular risk in women with MetS.
Eui Geum Oh, PhD, RN Professor, College of Nursing, Nursing Policy and Research Institution, Yonsei University, Seoul, Republic of Korea.
Soo Hyun Kim, PhD, RN Assistant Professor, Department of Nursing, Inha University College of Nursing, Incheon, Republic of Korea.
So Youn Bang, PhD, RN Assistant Professor, Department of Nursing, Youngdong University, Chungbuk, Republic of Korea.
Sa Saeng Hyun, PhD, RN Community Health Practitioner, Galsan Community Health Center, Chungju, Republic of Korea.
Jee-Aee Im, PhD Sports and Medicine Research Center, INTOTO, Inc, Seoul, Republic of Korea.
Jung Eun Lee, MS, RN Teaching Assistant, College of Nursing, Nursing Policy and Research Institution, Yonsei University, Seoul, Republic of Korea.
Jae Yong Yoo, MS, RN Teaching Assistant, College of Nursing, Nursing Policy and Research Institution, Yonsei University, Seoul, Republic of Korea.
This work was supported by the Korean Science and Engineering Foundation (R01-2006-000-11333-0). The authors have no conflicts of interest to disclose.
Correspondence Soo Hyun Kim, PhD, RN, Department of Nursing, Inha University, 253 Yonghyun-dong, Nam-gu, Incheon, Korea 401-752 (firstname.lastname@example.org).