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Assessing and Managing Metabolic Syndrome and Cardiovascular Risk in Midlife Women

Coviello, Jessica Shank DNP, APRN, ANP-BC; Knobf, M. Tish PhD, RN, FAAN, AOCN; Laclergue, Sarah BS

The Journal of Cardiovascular Nursing: March/April 2013 - Volume 28 - Issue 2 - p 147–156
doi: 10.1097/JCN.0b013e31823cbef8

Background: The components of metabolic syndrome (MetS), a major cardiovascular risk in women that includes diabetes, hypertension, and dyslipidemia, can evolve during the perimenopause transition. Lifestyle interventions have been shown to ameliorate or prevent individual components of MetS.

Purpose: This article will describe the hormonal and vascular changes occurring during perimenopause and discuss how they set the stage for MetS in women. The available screening tools (Framingham Assessment for Coronary Heart Disease vs Framingham General Cardiovascular Risk Profile vs Reynolds Risk Assessment) will be compared and contrasted within the context of the 2011 Updated Guidelines for the Prevention of Cardiovascular Disease in Women via case study.

Conclusions and Clinical Implications: Target goals and interventions to reduce or ameliorate the components of MetS will be presented, with a focus on achieving ideal cardiovascular health.

Jessica Shank Coviello, DNP, APRN, ANP-BC Associate Professor, School of Nursing, Yale University, New Haven, Connecticut.

M. Tish Knobf, PhD, RN, FAAN, AOCN Professor, School of Nursing, Yale University, New Haven, Connecticut.

Sarah Laclergue, BS Acute Care Nurse Practitioner Student, School of Nursing, Yale University, New Haven, Connecticut.

The authors have no funding or conflicts of interest to disclose.

Correspondence Jessica Shank Coviello, DNP, APRN, ANP-BC, 68 Brittany Drive, Durham, CT 0642 (

© 2013 Lippincott Williams & Wilkins, Inc.