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Reply “Co-analgesics for neuropathic pain in the rat model of spared nerve injury”

Lin, Wen-Yinga,b,c; Sun, Wei-Zenc,*; Yen, Chen-Tunga,*

Author Information

aDepartment of Life Science, National Taiwan University, Taipei, Taiwan, ROC

bNational Taiwan University Cancer Center, National Taiwan University College of Medicine, Taipei, Taiwan, ROC

cDepartment of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan, ROC

Received September 19, 2019; accepted October 1, 2019.

Conflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article

*Address correspondence: Prof. Wen-Zen Sun, Department of Anesthesiology, National Taiwan University Hospital, 7, Chung-Shan South Road, Taipei 100, Taiwan, ROC. E-mail address: [email protected] (W.-Z. Sun)

Prof. Chen-Tung Yen, Department of Life Science, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan, ROC. E-mail address: [email protected] (C.-T. Yen).

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Journal of the Chinese Medical Association: December 2019 - Volume 82 - Issue 12 - p 963
doi: 10.1097/JCMA.0000000000000213
  • Open

DEAR EDITOR,

We appreciate the recent correspondence by Chih-Jen Hung and Han-Fang Tseng regarding our article1 and welcome this opportunity to address their comments.2

We agree with Hung and Tseng that it is necessary to considered various aspects of the spared nerve injury (SNI) model. Our research team has been using the SNI model for many years. According to our previous published results,3–6 and the first SNI paper by Decosterd and Woolf,7 stable, consistent, and long-lasting mechanical and thermal-evoked pain behaviors developed within 3 days after SNI surgery, in sharp contrast to negative pain behaviors after sham surgery. We tested the drug effects only when the SNI-induced pain behaviors had been well established. Our previous experiments also presented with saline injection in the SNI rats to address the placebo effect.4 In this work, we focused on synergistic effects by the combination of drugs. MPE and AUC were chosen and presented because these indices match clinician’s perspective in managing neuropathic pain patients the best. Thus, we hope our article could provide preclinical reference in neuropathic pain managements.

REFERENCES

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2. Tseng HF, Hung CJ. Co-analgesics for neuropathic pain in the rat model of spared nerve injury.J Chin Med Assoc201982:962.
3. Lee KS, Huang YH, Yen CT. Periaqueductal gray stimulation suppresses spontaneous pain behavior in rats.Neurosci Lett201251442–5
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