Case Report: PDF OnlyPrimary Small Cell Carcinoma of the Stomach Successfully Treated With Cisplatin and EtoposideKuo, Shu-Chena, h; Chao, Yeeb, f, g; Luo, Jiing-Chyuana, g; Lee, Kuei-Chuana, g; Wu, Chew-Wunc, g; Li, Anna Fen-Yaud, g; Lee, Rheun-Chuane, g; Li, Chung-Pina, g, *Author Information aDivision of Gastroenterology, Department of Medicine, Taiwan, R.O.C. bCancer Center, Taiwan, R.O.C. cDivision of General Surgery, Department of Surgery, Taiwan, R.O.C. dDepartment of Pathology, Taiwan, R.O.C. eDepartment of Radiology, Taipei Veterans General Hospital, Taiwan, R.O.C. fCentral Clinic Hospital, Taiwan, R.O.C. gNational Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C. hNational Yang-Ming University Hospital, Yilan, Taiwan, R.O.C. *Correspondence to: Dr Chung-Pin Li, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C. E-mail: [email protected] Received: April 6, 2009; • Accepted: October 16, 2009. Journal of the Chinese Medical Association: November 2009 - Volume 72 - Issue 11 - p 598-602 doi: 10.1016/S1726-4901(09)70436-8 Metrics Abstract We report a 44-year-old man with primary gastric small cell carcinoma who showed a remarkable response to chemotherapy specific for pulmonary small cell carcinoma. The patient had been admitted to another local hospital because of intermittent epigastralgia. An upper gastrointestinal examination there revealed an ulcerative tumor, 5 cm in diameter, on the lesser curvature side of the cardia, and endoscopic biopsy reported adenocarcinoma. Computed tomography revealed a mass over the lesser curvature of the stomach and some enlarged regional lymph nodes. Radical total gastrectomy, lymph node dissection, Roux-en-Y esophagojejunostomy and splenectomy were performed at our hospital. Pathology revealed gastric mucosa infiltrated by small-sized tumor cells with scanty cytoplasm and hyperchromatic nuclei. Immunohisto- chemically, the tumor cells were positive for synaptophysin, chromogranin A, and CD56. Primary gastric small cell carcinoma was diagnosed. The postoperative course, complicated by shock due to bleeding, wound infection and intra-abdominal abscess, took more than 2 months to resolve. Follow-up computed tomography showed tumor recurrence with multiple enlarged lymph nodes in the aortocaval region and hepatic hilum. The patient received palliative chemotherapy consisting of cisplatin 80 mg/m2 on day 1 and etoposide 80 mg/m2 on days 1–3 every 28 days, and had partial response to the chemotherapy, with a progression-free survival of 10 months. Chemotherapy with cisplatin and etoposide used for small cell carcinoma of the lung is a good treatment for gastric small cell carcinoma. © 2009 by Lippincott Williams & Wilkins, Inc.