CASE REPORT: PDF OnlyPrimary Vaginal Extraosseous Ewing Sarcoma/Primitive Neuroectodermal Tumor with Cranial MetastasisYip, Chi-Mana, *; Hsu, Shu-Shonga; Chang, Nai-Jenb; Wang, Jyh-Sengc; Liao, Wei-Chuana; Chen, Jun-Yiha; Liu, Su-Haoa; Chen, Chih-HaoaAuthor Information aDivision of Neurosurgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C. cDepartment of Pathology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C. bDivision of Pathology, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C. *Correspondence to: Dr Chi-Man Yip, Division of Neurosurgery, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung 813, Taiwan, R.O.C. E-mail: [email protected] Received: July 31, 2008; • Accepted: February 3, 2009. Journal of the Chinese Medical Association: June 2009 - Volume 72 - Issue 6 - p 332-335 doi: 10.1016/S1726-4901(09)70381-8 Metrics Abstract Extraosseous Ewing sarcoma is now regarded as a member of the Ewing sarcoma/primitive neuroectodermal tumor (PNET) family. It typically involves the soft tissues of the chest wall, pelvis, paravertebral region, abdominal wall, retroperitoneal region and extremities of children, adolescents and young adults, but it seldom occurs in the female genital tract. We report an extremely rare case of retrospective diagnosis of vaginal extraosseous Ewing sarcoma/PNET which metastasized to the right frontoparietal scalp, skull, and dura. Surgical resection, followed by adjuvant radiotherapy and chemotherapy resulted in a favourable clinical outcome. Both the vaginal and head tumors had similar light microscopic features supporting the diagnosis. © 2009 by Lippincott Williams & Wilkins, Inc.