Case Report: PDF OnlyReversible Myelopathy on Magnetic Resonance Imaging Due to Cobalamin DeficiencyLee, Wei-Jua; Hsu, Hung-Yia, b; Wang, Pao-Yua, b, *Author Information aDivision of Neurology, Department of Medicine, Taichung Veterans General Hospital, Taiwan, R.O.C. bNational Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C. *Correspondence to: Dr Pao-Yu Wang, Division of Neurology, Department of Medicine, Taichung Veterans General Hospital, 160, Section 3, Taichung-Kang Road, Taichung 407, Taiwan, R.O.C E-mail: [email protected] Received: October 3, 2007; • Accepted: February 29, 2008. Journal of the Chinese Medical Association: July 2008 - Volume 71 - Issue 7 - p 368-372 doi: 10.1016/S1726-4901(08)70142-4 Metrics Abstract Subacute combined degeneration (SCD) is known as myelopathy due to vitamin B12 deficiency. SCD always involves the posterior and lateral columns of the spinal cord, with the neuropathologic change showing vacuolation of the white matter. We describe 2 patients who presented with ataxic gait, impaired proprioception over limbs, and even mental change due to vitamin B12 deficiency. Magnetic resonance imaging (MRI) of the cervical spine showed increased signal intensity on T2-weighted imaging, and laboratory data showed low serum vitamin B12 level. The 2 patients were treated with vitamin B12 injection intramuscularly. There was clinical improvement after treatment along with normalization of the MRI. © 2008 by Lippincott Williams & Wilkins, Inc.