Case Report: PDF OnlyDermatitis Herpetiformis and VitiligoKarabudak, Ozlema, *; Dogan, Bilala; Yildirim, Sukrub; Harmanyeri, Yavuza; Anadolu-Brasie, Ranac Author Information aDepartments of Dermatology and Ankara University Medical School, Ankara, Turkey bDepartments of Pathology, GATA Teaching Hospital, Istanbul, and Ankara University Medical School, Ankara, Turkey cDepartment of Dermatology, Ankara University Medical School, Ankara, Turkey *Correspondence to: Dr Ozlem Karabudak, Department of Dermatology, GATA Teaching Hospital, Tibbiye Street 81327 Kadikoy, Istanbul, Turkey E-mail: [email protected] Received: January 19, 2007; • Accepted: October 9, 2007. Journal of the Chinese Medical Association: November 2007 - Volume 70 - Issue 11 - p 504-506 doi: 10.1016/S1726-4901(08)70049-2 Metrics Abstract Dermatitis herpetiformis (DH) is a rare immunobullous disorder of the skin that is associated with gluten hypersensitivity. Subepidermal IgA-type antibody deposition against tissue transglutaminase leads to dense neutrophilic microabscess and eventually into vesicles in dermal papillae, which may occasionally merge into bullae. Being a subepidermal vesiculobullous disorder, DH is frequently associated with postinflammatory pigmentary changes, particularly hypopigmentation. However, the association of DH with true vitiligo is extremely rare. Here, we report a 21-year-old male with vitiligo and comorbid DH, and review the literature. This new case had severely pruritic, papular and papulovesicular lesions that were localized symmetrically and partly confined to the pre-existing vitiliginous areas. The skin biopsy specimen taken from an erythematous papule on the elbow showed characteristic findings of DH and vitiligo. Direct immunofluorescence microscopy of the perilesional skin revealed granular IgA deposition of dermal papillae. There are only 10 reports in the literature of DH and vitiligo comorbidity. © 2007 by Lippincott Williams & Wilkins, Inc.