Case Report: PDF OnlyPrimary Lymphohistiocytic Variant of Anaplastic Large Cell Lymphoma of the StomachYang, Chii-Shuenna; Chou, Guana, *; Jan, Yee-Jeea, d; Wang, Johna, d; Yeh, Dah-Cherngb; Teng, Chieh-Linc Author Information aDepartment of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C. bDepartment of General Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C. cDepartment of Hematology and Oncology, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C. dCollege of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C. *Correspondence to: Dr Guan Chou, Department of Pathology, Taichung Veterans General Hospital, 160, Section 3, Taichung-Kang Road, Taichung 407, Taiwan, R.O.C. E-mail: [email protected] Received: June 30, 2006; revised December 7, 2006. Journal of the Chinese Medical Association 70(2):p 71-75, February 2007. | DOI: 10.1016/S1726-4901(09)70305-3 Metrics Abstract Here, we report an unusual case of gastric anaplastic large cell lymphoma (ALCL), lymphohistiocytic variant, in a 70-year-old female patient who presented with epigastric pain, tarry stool and body weight loss. Endoscopic and imaging findings revealed a Bormann type II tumor in the stomach with perigastric lymphadenopathy and multiple tumor nodules in the liver. Total gastrectomy and liver biopsy were performed. Histologically, both gastric and hepatic tumors demonstrated anaplastic large neoplastic cells scattered among numerous reactive histiocytes. Immunostaining of these tumor cells reacted positively for CD30, CD3, CD45RO/UCHL1, and negatively for epithelial membrane antigen, CD68, lysozyme, CD15, CD79a, CD138, PAX5 and anaplastic lymphoma kinase. Both the morphologic and immunophenotypic findings supported the diagnosis of gastric ALCL of lymphohistiocytic variant with liver metastasis. This patient then received chemotherapy and was still alive after 17 months of follow-up, without evidence of residual disease. © 2007 by Lippincott Williams & Wilkins, Inc.