Case Report: PDF OnlyMalignant Ganglioneuroma Arising from Mediastinal Mixed Germ Cell TumorChen, Pi-Yua; Chen, Winby York-Kwanb, c, *; Ho, Donald M.T.b, c; Pan, Chin-Chenb, c Author Information aDepartment of Pathology, Chia-Yi Veterans General Hospital, Taipei, Taiwan, R.O.C. bTaipei Veterans General Hospital, Taipei, Taiwan, R.O.C. cNational Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C. *Correspondence to: Dr Winby York-Kwan Chen, Department of Pathology, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, R.O.C. E-mail: [email protected] Received: July 26, 2006; revised December 8, 2006. Journal of the Chinese Medical Association 70(2):p 76-79, February 2007. | DOI: 10.1016/S1726-4901(09)70306-5 Metrics Abstract Mixed germ cell tumors with non-germ cell malignant components rarely occur in the anterior mediastinum. We report a case of a 34-year-old man who presented with an anterior mediastinum mass. Mixed germ cell tumor was initially diagnosed based on the pathologic findings of germinoma on thoracoscopic biopsy and clinical findings of elevated serum a-fetoprotein and β-human chorionic gonadotropin. The patient received preoperative chemotherapy and subsequent complete resection of the residual tumor. Pathologic examination of the excised specimen showed predominantly malignant ganglioneuroma and small residual foci of teratoma. To our knowledge, this is the first reported case of a malignant ganglioneuroma arising from mediastinal mixed germ cell tumor. © 2007 by Lippincott Williams & Wilkins, Inc.