Case Report: PDF OnlySpontaneous Rupture of Recurrent Gastrointestinal Stromal Tumor Associated with Neurofibromatosis Type 1Wang, Shin-Maea; Chiang, Ruey-Anb; Tzen, Chin-Yuanc; Cheng, Shih-Pinga; Liu, Tsang-Paia, d, * Author Information aDepartment of Surgery, Nursing and Management College, Taipei, Taiwan, R.O.C. cDepartment of Pathology, Mackay Memorial Hospital, Taipei, Taiwan, R.O.C. bDepartment of Surgery, Mackay Memorial Hospital, Taitung Branch, Taipei, Taiwan, R.O.C. dDepartment of Mackay Medicine, Nursing and Management College, Taipei, Taiwan, R.O.C. *Correspondence to: Dr. Tsang-Pai Liu, Department of Surgery, Mackay Memorial Hospital, 92, Section 2, Chung-Shan North Road, Taipei 104, Taiwan, R.O.C. E-mail: [email protected] Received: November 26, 2004 • Accepted: April 15, 2005 Journal of the Chinese Medical Association: November 2005 - Volume 68 - Issue 11 - p 538-541 doi: 10.1016/S1726-4901(09)70090-5 Metrics Abstract The incidence of gastrointestinal stromal tumor (GIST) among neurofibromatosis type 1 (NF-1) patients is approximately 3.9–25%, and this relationship is generally considered to be non-coincidental. We report a patient with NF-1 who underwent laparotomy 3 times due to recurrent intra-abdominal tumor rupture with internal bleeding in the space of 13 years. The pathologic diagnoses were schwannoma, malignant peripheral nerve sheath tumor and GIST. Because of the similar histologic features of these tumors, we considered them to be of the same nature. Immunohistochemical staining can help in the differential diagnosis. We suggest that NF-1 patients with gastrointestinal symptoms receive further survey to rule out GISTs. © 2005 by Lippincott Williams & Wilkins, Inc.