From the ∗Department of Internal Medicine, Oulu University Hospital
†Research Unit of Biomedicine, University of Oulu
‡Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital and University of Oulu
§Department of Clinical Genetics, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu
∥Institute of Biotechnology, Helsinki Institute of Life Science (HiLIFE), University of Helsinki
¶Clinicum, Faculty of Medicine, University of Helsinki, Helsinki
#Department of Infection Control, Lapland Central Hospital, Rovaniemi
∗∗Department of Obstetrics and Gynecology, Oulu University Hospital
††Hematology Laboratory, Nordlab Oulu, Oulu University Hospital
‡‡Department of Pathology, Cancer Research and Translational Medicine Research Unit, University of Oulu and Oulu University Hospital
§§Respiratory Medicine, Research Unit of Internal Medicine, University of Oulu and Medical Research Center Oulu
∥∥Department of Radiology, Oulu University Hospital
¶¶Department of Ophthalmology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital and University of Oulu
##Department of Dentistry, Oulu University Hospital
∗∗∗Department of Dermatology, Oulu University Hospital, Oulu
†††Institute for Molecular Medicine Finland, Helsinki Institute of Life Science (HiLIFE)
‡‡‡Proteomics Unit, Institute of Biotechnology, University of Helsinki
§§§Department of Rheumatology, Inflammation Center, University of Helsinki and Helsinki University Hospital. Research Institute, Invalid Foundation. Orton Orthopedic Hospital
∥∥∥Rare Diseases Center and Pediatric Research Center, Children and Adolescents and Adult Immunodeficiency Unit, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
The study has been approved by ethical committee of Oulu University Hospital. Informed consent was obtained. The study was conducted according to the guidelines of Declaration of Helsinki.
Funding was provided by Oulu and Helsinki University Hospital Research Funds.
The authors declare no conflict of interest.
Authors' Contributions: T.H., P.V., A.V., M. Simojoki, M. Säily, R.K., N.H., S. Kantola, and P.J. were responsible for treatment and follow-up of treatment outcome. S. Keskitalo, K.R., I.P., V.G., M.V., and K.K.E. completed immunological analysis. H.K. and M.M. analyzed tissue histology. A.J. completed radiological analysis. O.K. and J.S. completed genetic analysis. T.H., K.K.E., and M.R.J.S. were responsible for study design. All authors read and approved the final manuscript.
Correspondence: Timo Hautala, MD, PhD, Research Unit of Biomedicine, University of Oulu, PO Box 20, FIN-90029 OYS, Finland. E-mail: [email protected].
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