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Osteoarthritis in Latin America: Study of Demographic and Clinical Characteristics in 3040 Patients

Reginato, Anthony M. PhD, MD*; Riera, Humberto PhD, MD; Vera, Mariflor MD; Torres, Adrian R. MD; Espinosa, Rolando PhD, MD§; Esquivel, Jorge A. MD; Felipe, Oscar Jair MD; Blas, Jorge Roman MD#; Rillo, Oscar MD**; Papasidero, Silvia MD**; Souto, Renee MD††; Rossi, Cesar MD††; Molina, José F. PhD, MD‡‡; Ballesteros, Francisco MD§§; Radrigan, Francisco MD∥∥; Guibert, Marlene MD¶¶; Chico, Araceli MD##; Gil, María L. MD***; Camacho, Walter MD†††; Urioste, Lorena MD‡‡‡; Garcia, Abraham K. MD§§§; Iraheta, Isa MD§§§; Gutierrez, Carmen E. MD∥∥∥; Duarte, Margarita MD¶¶¶; Castañeda, Oswaldo MD###; Coimbra, Ibsen MD****; Muñoz Louis, Roberto MD††††; Reveille, John PhD, MD‡‡‡‡; Quintero, Maritza PhD, MDThe Pan-American League of Associations for Rheumatology (PANLAR) Osteoarthritis Study Group

JCR: Journal of Clinical Rheumatology: December 2015 - Volume 21 - Issue 8 - p 391–397
doi: 10.1097/RHU.0000000000000281
Original Articles

Background Latin America is a heterogeneous region made up of different populations, cultures, latitudes, altitudes, and immigrants from different areas and ethnic groups.

Objective The purpose of this study is to describe the clinical and demographic profile of patients with osteoarthritis (OA) evaluated by a selected group of rheumatologists in 13 Latin American countries.

Methods A descriptive, observational, cross-sectional study was conducted in 13 Latin American countries of patients with symptomatic OA. Data were collected over a 3-month period using an ad hoc questionnaire to evaluate the clinical and demographic features of OA seen by rheumatologists.

Results Among the 3040 patients, their average age was 62.5 years, and female-to-male ratio was 4.8:1. Patients with body mass index of greater than 30 kg/m2 or obesity was found in 38.2%. Approximately 88% had primary OA. Joints with OA were as follows: knee 31.2%, hand 9.5%, hand and knee 22.9%, proximal and distal interphalangeal joints (erosive OA) 6.5%, axial 6.6%, and hip 1.3%. Approximately 88.5% had radiographic severity of grade 2 or 3 on Kellgren-Lawrence scale (0–4). Nonsteroidal anti-inflammatory drugs were the predominant OA treatment included in combinations with glucosamine sulfate/chondroitin and viscosupplementation. Associated comorbidities included hypertension (39%), obesity (36.3%), diabetes mellitus (12%), and without comorbidity (12.7%).

Conclusions This is 1 of the largest population studies that evaluated the characteristics of OA in 3040 patients evaluated by rheumatologists in 13 Latin American countries. This study provides important data for each Latin American country to develop new health care planning in management of OA.

From the *Division of Rheumatology, The Warren Alpert School of Medicine, Providence, RI; †Unidad de Reumatología, Instituto Autónomo Hospital Universitario de Los Andes, Universidad de Los Andes; and ‡LabMice, Universidad de Los Andes, Mérida, Venezuela; §Departamento de Reumatología, Instituto Nacional de Rehabilitación, México City; and ∥Departamento de Medicina Interna, Servicio de Reumatologia, Universidad Autonoma de Nuevo León, Mexico; ¶National Coordinator of Rheumatology and the Arthritis Clinical Research Unit at Medicarte, Medellin, Colombia; #Bone and Joint Research Unit, Fundación Jimenez Díaz, Madrid, Spain; **Servicio de Reumatología del Hospital Dr E. Tornu, Buenos Aires, Argentina; ††Catedra de Reumatología de la Facultad de Medicina de la Universidad de la Republica, Montevideo, Uruguay; ‡‡Departamento de Reumatología de la Universidad CES, Medellin, Colombia; §§Departamento de Reumatología, Universidad de Chile; and ∥∥Departamento de Reumatología, Universidad Católica de Chile, Santiago, Chile; ¶¶Servicio de Reumatología del Hospital Quirúrgico 10 de Octubre and ##Servicio de Reumatología del Hospital Frank País, Havana, Cuba; ***Servicio de Reumatología Hospital Santa Cruz, Caja Petrolera de Salud Techo Académico Universidad Católica San Pablo; †††Servicio de Medicina Interna del Hospital Obrero N° 3 de la Caja Nacional de Salud, Santa Cruz, Universidad Santo Tomas De Aquino, Santa Cruz; and ‡‡‡Servicio de Reumatología Kolping y Hospital Alfonzo Gumucio-Techo Académico Universidad Católica San Pablo, San Pablo, Bolivia, §§§Post-Grado de Reumatología, AGAR, FM, UFM, Facultad de Medicina, Universidad Francisco Marroquín, Ciudad de Guatemala, Guatemala; ∥∥∥Servicio de Reumatología, Instituto Salvadoreño del Seguro Social, San Miguel, El Salvador; ¶¶¶Servicio de Reumatología del Hospital de Clínicas de Asunción, Universidad Nacional de Asunción, Asunción, Paraguay; ###Profesor de Medicina Universidad Peruana de Ciencias Aplicadas UPC y Chairman Servicio Reumatología British American Hospital, Lima, Perú; ****Departamento de Clínica Médica da Faculdade de Ciências Médicas da UNICAMP- Universidade Estadual de Campinas, Campinas, São Paulo, Brazil; ††††Servicio de Reumatología Hospital Docente Padre Billini, Clínica Abreu, Santo Domingo, Dominican Republic; and ‡‡‡‡The University of Texas Health Science Center at Houston, Houston, TX.

Patient consent was obtained. The ethics committee of the Universidad de Los Andes, Mérida, Venezuela, and participating institutions from 13 Latin American Countries provided ethics approval.

This work was supported by a grant from PANLAR (to M.Q.) and National Institutes of Health grant P20GM104937-05 (to A.M.R.).

The authors declare no conflict of interest.

Correspondence: Maritza Quintero, PhD, Instituto Autónomo Hospital Universitario de Los Andes-Unidad de Reumatología-Facultad de Medicina-Universidad de Los Andes. Av 16 de septiembre. Parroquia Domingo Peña, Mérida-5101. E-mail:

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