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Exercise as an Adjuvant Treatment in Persistent Active Polymyositis

Mattar, Melina Andrade MD*; Gualano, Bruno PhD*†; Roschel, Hamilton PhD*†; Perandini, Luiz Augusto MSc*; Dassouki, Thalita BS*; Lima, Fernanda Rodrigues MD, PhD*; Shinjo, Samuel Katsuyuki MD, PhD*; de Sá Pinto, Ana Lúcia MD, PhD*

Journal of Clinical Rheumatology: January 2014 - Volume 20 - Issue 1 - p 11–15
doi: 10.1097/RHU.0000000000000056
Original Articles

Objectives A growing number of studies have suggested that exercise may promote therapeutic effects in patients with idiopathic inflammatory myopathy. This prospective case series study aimed to report on the effects of exercise in patients with persistent active myositis.

Methods Three patients with persistent active polymyositis were submitted to a 12-week supervised exercise program comprising both aerobic and strength exercises.

Results After the intervention, the patients presented improvements in selected parameters of muscle function and aerobic conditioning. In addition, an overall improvement was detected in the quality of life, as measured by both the 36-item Short-Form Health Survey and the Health Assessment Questionnaire questionnaires. Importantly, exercise did not increase serum levels of creatine kinase and aldolase.

Conclusions The findings herein suggest that a combined aerobic and strength training program may be tolerable and potentially effective in improving muscle function, aerobic conditioning, and quality of life in patients with persistent active polymyositis.

From the *School of Medicine, Rheumatology Division; and †School of Physical Education and Sport, Brazil.

The authors declare no conflict of interest.

Correspondence: Hamilton Roschel, PhD, Faculdade de Medicina, Universidade de São Paulo, 3° andar–sala 3131 Divisão de Reumatologia Av Dr Arnaldo, 455–Cerqueira César, São Paulo, Brazil. E-mail: hars@usp.

© 2014 by Lippincott Williams & Wilkins, Inc.