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Insufficiency Fracture Associated With Oncogenic Osteomalacia

Niemeier, Thomas BS; Leddy, Lee MD; Bolster, Marcy MD; Chapin, Russell MD

JCR: Journal of Clinical Rheumatology: January 2013 - Volume 19 - Issue 1 - p 38–42
doi: 10.1097/RHU.0b013e31827cd112
Case Reports

Oncogenic osteomalacia is a rare paraneoplastic syndrome of systemic bone demineralization secondary to a tumor-induced dysregulation of phosphorus metabolism. The tumor’s low prevalence, small size, and variable location often result in years of muscular weakness and bone pain before diagnosis. With complete treatment, patient’s symptoms swiftly dissipate. We report the case of a 63-year-old previously healthy man with a 20-month course of musculoskeletal symptoms before diagnosis and resection of a posterior tibial tumor. Postoperatively, the patient had returned to his previous lifestyle when an insufficiency fracture required prophylactic stabilization.

From the Medical University of South Carolina, Charleston, SC.

The authors declare no conflict of interest.

Correspondence: Lee Leddy, MD, Medical University of South Carolina, 96 Jonathan Lucas St, MSC 622, Charleston, SC 29425. E-mail:

© 2013 Lippincott Williams & Wilkins, Inc.