Case ReportsTreatment of Ankylosing Spondylitis by Extracorporeal Photochemotherapy Given for Mycosis Fungoides: A Potential Treatment Option?Akay, Bengu Nisa MD*; Sanli, Hatice MD*; Kutlay, Sehim MD†Author Information From the Departments of *Dermatology and †Physical Therapy and Rehabilitation, School of Medicine, University of Ankara, Ankara, Turkey. There are no funding sources for this study. Correspondence: Bengu Nisa Akay, MD, Ankara Universitesi Tip Fakultesi, Ibni Sina Hastanesi Dermatoloji Anabilim Dalı, 06100 Samanpazari, Ankara, Turkey. E-mail: firstname.lastname@example.org. Journal of Clinical Rheumatology: August 2011 - Volume 17 - Issue 5 - p 278-280 doi: 10.1097/RHU.0b013e3182287f59 Buy Metrics AbstractIn Brief We describe a patient with cutaneous T-cell lymphoma (CTCL), in association with concurrent ankylosing spondylitis (AS), who achieved a long-lasting complete remission of both diseases after 3 cycles of extracorporeal photochemotherapy (ECP). The combination of CTCL with AS is very rare. In our patient, the CTCL was refractory to psoralen-UVA. He was unable to continue with administration of interferon α because of exacerbation of his back, anterior chest, and bilateral heel pain. The Bath AS Functional Index and Bath AS Disease Activity Index scores were determined to be 2.2 and 5.8, respectively. Extracorporeal photochemotherapy has been shown to be effective in the treatment of CTCL consisting of reinfusion of 3 to 9 × 109 leukocytes, taken from the patient by leukopheresis and treated in an extracorporeal system with 8-methoxypsoralen and UVA. There is a strong suggestion that ECP as a monotherapy can provide a significant benefit for other T-cell-mediated diseases including rheumatoid arthritis and psoriatic arthritis. This is the first report describing an effective treatment of AS in which pain, inflammatory response, Bath AS Disease Activity Index, and Bath AS Functional Index improved after initiation of ECP. This 51-year-old man had dramatic improvement in many features of his AS. © 2011 Lippincott Williams & Wilkins, Inc.