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Vitamin D, Immunoregulation, and Rheumatoid Arthritis

Wen, Hongyan MD*†‡; Baker, Joshua F. MD

Journal of Clinical Rheumatology: March 2011 - Volume 17 - Issue 2 - p 102-107
doi: 10.1097/RHU.0b013e31820edd18

In addition to being important in calcium and phosphorus metabolism, bone formation, and mineralization, vitamin D also plays a part in the maintenance of immune homeostasis. Vitamin D receptors are expressed in a number of different tissues, including, and perhaps most notably, on immune cells. The presence or absence of activated vitamin D has a number of effects on in vitro immune cell function. This review describes the possible immunoregulatory role of vitamin D in rheumatoid arthritis with clinical and animal studies.

From the *Shanxi Medical University, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, China; †Division of Rheumatology, Department of Medicine, University of Pennsylvania; and ‡VA Medical Center, Philadelphia, PA.

No funding support was received for this study.

The authors have nothing to disclose.

Correspondence: Hongyan Wen, MD, Shanxi Medical University, No. 56 Xinjian Road South, Taiyuan, Shanxi Province 030001, China. E-mail:

© 2011 Lippincott Williams & Wilkins, Inc.